Ohemaa Mercy started her primary education at St Peter's Anglican Primary School in Koforidua and proceeded to Ghana Secondary School where she had her secondary education. She continued to the teachers training College at S.D.A Teachers Training College, Asokore Koforidua where she obtained her Teacher's Certificate ‘A'.
Ohemaa Mercy released her first album in the latter part of November 2004. Entitled Adamfo Papa, the album enjoyed massive airplay after its release, which brought Ohemaa into the limelight. She won seven nominations for the 2006 Ghana Music Awards but did not win any of the awards. She later won the Discovery of the year for the Gospel Music Awards the same year.
In 2007, the gospel minister released her second album, Edin Jesus. Ohemaa Mercy sold 875,000 copies six months after releasing the second album making it the best-selling album of the year.
The Edin Jesus album gave Ohemaa Mercy 10 nominations for the 2008 Ghana Music Awards. This was the highest number of nominations so far in the history of the awards scheme. At the event she managed to take home three awards: Gospel Artiste of the Year, Album of the Year and Gospel Album of The Year. In the same year she won a Grand Medal During the National Honours Award from the ex-President of Ghana, John Kufuor.
In 2010–11 Ohemaa released her third album, Wobeye Kese, which again was the highest selling album and topped all the major chat shows in the country. Four months after its release this album again won her four nominations at the 2014 Ghana Music Awards.
She won the Gospel Artiste of the year and in Canada the same year was Gospel Artiste of the Year-Canada. She was nominated the Best Female Artiste West Africa the same year for the Africa Gospel Music awards in London.
Ohemaa Mercy has performed on major platforms with electrifying performances that have earned her a huge fun base, not only for the love of her music but also for her stage performances. Ohemaa has shared the stage with renowned international artistes such as Andrae Crouch, Israel Houston, Don Moen, Darwin Hobbs, Juanita Bynum, Kirk Franklin, Fred Hammond, to mention a few. With her latest album Aforebo, Ohemaa Mercy has six successful albums to her credit.
TODAY October 26, 2016 - Report reaching GhanaSky.com and Accra24.com indicate that, the Gospel minister Ohemaa Mercy and her husband, Mr Isaac Twum Ampofo celebrate fourteen years of marriage.
According GhanaSky.com analyst, Ohemaa Mercy wrote on her Facebook wall:
“14yrs ago this union was blessed at the Church of Pentecost English Assembly Koforidua. I am grateful to Jesus for standing with us through it all like he promised when he put us together. He has been faithful. We know our union makes him proud and so are we the pride of all who witness that day.
Friends and family help us say thank you to God for keeping to his covenant with us. We stand on this and Declare that if there is anyone praying for marriage reading this, may Jesus connect him or Her to a destined man or woman. We know when we speak God has work to do.
May it be done in Jesus name. We pray for peace in all marriages and pray for love to dwell in homes going through the trial moments of marriage. God bless you all.
Ohemaa Mercy and hubby have three son; Kofi Nyamekye Twum Ampofo – 13 and 9 year old Kofi Nhyira Twum Ampofo.