The party cited some comments made by the president during his recent visit to the Volta Region as reason for their accusation.
The president told the chiefs and people of the Volta Region that every development project executed in the region was done by the National Democratic Congress and not the New Patriotic Party.
The president took a swipe at the NPP for claiming the residents in the Volta Region have been disappointed in the performance of the governing party.
On the contrary, the president said the NDC has and continues to invest in infrastructure in the region.
"We will not be distracted," he said adding, "we have built a new campus. The Volta Region did not have a university but under NDC there is one now. There is also the school of pharmacy which is coming to Keta.
"This government stands for you and will make sure the region gets its fair share of development," he stated.
But the NPP is accusing the president of pitching the Volta Region against them.
The first to speak on the matter was the Director of Communications of the NPP Nana Akomea who suggested that the president had no business mentioning the NPP when he was addressing the concerns of the residents in the region.
According to him, the Chief in the Volta Region Togbui Sri had complained about the poverty and the harsh living conditions the people in the region were enduring but he found it rather surprising that instead of addressing the concerns of the residents, the president rather decided to speak about the supposed NPP record in the Volta Region.
The Chairman of the New Patriotic Party Peter Amewu in a reaction on Joy News said the president's claim that the NPP did not execute any development project in the Volta Region is palpably false.
He said even the road on which the president travelled to Aflao was constructed by the NPP. He also chronicled a number of projects in the region which he said were executed by the NPP.
He said the president's half truths can only be a mark of desperation.
The Communications Minister Dr Omane Boamah told Joy News' Evans Mensah the NPP is running away from its bad record in the Volta Region.
He said very soon the opposition party will run away from its record of poor infrastructural development in the other nine regions.
"Mahama will never engage in tribal politics," he said, accusing the NPP of being champions of tribal politics.